Financial Support of Research Projects

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Ongoing projects/grants:

International:

  1. •National Institute of Environmental Health Sciences (2R01ES013773-06A1). Nucleoprotein structures at telomeres and sites of DNA damage. [09/2011-04/2016, 30000 EUR, Ľ. Tomáška: foreign collaborator; principal investigator: Prof. Jack D. Griffith, University of North Carolina, Chapel Hill, NC, USA]


National:

Slovak Research and Development Agency (APVV):

  1. •APVV 0035-11 - Comparative and functional analysis of nuclear telomeres (2012-2015) (LT)


Slovak Grant Agency VEGA:

  1. •VEGA 1/0333/15 - Comparative and functional analysis of the metabolic gene clusters in eukaryotic genomes (2015-2018) (JN)

  2. •VEGA 1/0311/12 - Molecular mechanisms mediating the effect of ionophores on membrane compartments of eukaryotic cells  (2012-2015) (LT)


Previous projects/grants:

International:

  1. •Howard Hughes Medical Institute International Research Grant (#55005622) Molecular architecture and dynamics of mitochondrial chromosomes: A paradigm for evolution and maintenance of linear DNA genomes. (2006-2011) (JN)

  2. •Grant International Visegrad Fund [no.13073-2007-IVF] A grant to support summer school on ‘Biology of pathogenic Candida species: molecular diagnostics, genetics and genomics‘, Szeged, Hungary (2008); (JN with Prof. Judit Kucsera, University of Szeged, Hungary)

  3. •Grant The Ellison Medical Foundation to support XXII. International Conference on Yeast Genetics and Molecular Biology. (2005); (LT with Prof. Jack D. Griffith, University of North Carolina, Chapel Hill, USA)

  4. •Grant UNESCO-ROSTE. TALNET: Workshop for boosting a systematic search of talents in Eastern Europe (2005) (LT)

  5. •Fogarty International Research Collaboration Award (1-R03-TW05654-01, CFDA No. 93934) Studies of telomere structure using yeast model systems. (2001-2005) (JDG, LT)

  6. •Fogarty International Research Collaboration Award, USA (2 R03 TW005654-04A1) Studies of telomere structure using yeast model systems. (2006-2009) (JDG, LT)

  7. •Howard Hughes Medical Institute International Research Scholars Grant (#55000327) Evolutionary and developmental tinkering of modules for alternative, telomerase-independent replication of linear genomes. (2001-2005) (JN)

  8. •Howard Hughes Medical Institute International Research Scholars Grant (75195-547301) Transfer of Cell Organelles and the use of Nontraditional Yeast Species in the Study of Nuclear-Cytoplasmic Relationships. (1995-2000) (LK, JK)

  9. •International Research Grant Program of University Complutense Madrid and "Alexander Dubček Department" at Comenius University Bratislava. Role of nucleo-mitochondrial interactions in a homeostasis of the eukaryotic cell. (2000-2001) (LT)

  10. •Open Society Fund Grant (G/37/97) Computer analysis of DNA and protein sequences in biological research and education (1997) (LT)

  11. •Open Society Fund Grant (GH/174/97) Cooperation in the study and education of taxonomy and genetics of non-conventional yeast species. (1997) (LT)


National:

Slovak Research and Development Agency APVV / Slovak Agency for Science and Technology APVT:

  1. •APVV 0123-10 - Molecular architecture, dynamics and evolution of chromosomes in yeast mitochondria (2011-2014) (JN)

  2. •APVV LPP-0063-07 - Motivation of high school students for life sciences using combination of selective and nonselective popularization activities. (2008-2011) (LT)

  3. •APVV 0024-07 - Molecular mechanisms implicated in the control of mitochondrial integrity in eukaryotic cells. (2008-2011) (JN)

  4. •APVV LPP-0164-06 - Analysis of the molecular architecture and dynamics of mitochondrial chromosomes. (2006-2010) (JN)

  5. •APVT 20-001604 - Functional analysis of the nucleo-protein structure of yeast telomeres. (2005-2007) (LT)

  6. •APVT 20-003902 - The study of complex biological phenomena at the level of functional analysis of yeast genomes. (2002-2004) (JN)


Slovak Grant Agency VEGA:

  1. •VEGA 1/0405/11 - Functional analysis of genes implicated in the control of hydroxyaromatic compounds metabolism in the pathogenic yeast Candida parapsilosis (2011-2014) (JN)

  2. •VEGA 1/0132/09 - Relationships between ion homeostasis and organelle dynamics in eukaryotic cells. (2009-2011) (LT)

  3. •VEGA 1/0219/08 - Molecular-genetic analysis of dimorphism of the pathogenic yeast Candida parapsilosis. (2008-2010) (JN)

  4. •VEGA 1/3247/06 - Regulation of yeast mitochondrial biogenesis: Roles of ion transport and protein phosphorylation. (2006-2008) (LT)

  5. •VEGA 1/2331/05 - Molecular analysis of functional elements involved in the control of replication and segregation of mitochondrial genomes (2005-2007) (JN)

  6. •VEGA 1/0006/03 - Nucleo-mitochondrial interactions and their role in yeast morphogenesis and bioenergetics (2003-2005) (LT)

  7. •VEGA 1/7248/20 - Role of organellar interactions in the evolution and morphogenesis of the eukaryotic cell. (2000-2002) (LT)

  8. •VEGA 1/9153/02 - Alternative pathways of telomere replication: The molecular architecture and the replication of telomeric structures of linear DNA genomes. (2002-2004) (JN)

  9. •VEGA 1/6168/99 - Alternative mechanisms of telomere replication: Linear mitochondrial DNA of yeast as a model system. (1999-2001) (JN)

  10. •VEGA 1/1161/94 - Non-traditional yeast species in a study of nucleo-mitochondrial interactions. (1994-1997) (LK)

  11. •VEGA 1/2173/95 - The study of interactions between nuclear and mitochondrial genomes in yeast-like microorganisms: The model of regulation of the replication and expression of linear mitochondrial DNAs. (1995-1998) (JN)

  12. •VEGA 1/4164/97 - Study of nonconventional yeast species in health protection against fungal pathogens. (1997-1999) (LT)

  13. •VEGA 1/4159/97 - Nucleo-cytoplasmic interactions studied by the interspecific transfer of cellular organelles using non-traditional yeast species (1997-1999) (LK)


Slovak Grant Agency KEGA:

  1. •KEGA 3/3021/05 - TalNet: Building a network for talent recruitment in biomedical sciences. (2005-2007) (LT)


Slovak Ministry of Education support for innovation of laboratory infrastructure:

  1. •2005 - Application of biolistics in the functional analysis of genomes in eukaryotic organelles (JN)


Comenius University grants for young investigators and PhD students:

2012

  1. •UK/297/2012 - Functional analysis of the gene CPAG03406 coding for a transcriptional activator of the gentisate pathway in the yeast Candida parapsilosis (MJ)

  2. •UK/260/2012 - Yeast mitochondria as a model for investigation of the catalytic subunit of mammalian telomerase (LS)

  3. •UK/239/2012 - Comparative analysis of mitochondrial DNA packaging proteins from yeasts (JP)

2011

  1. •UK/40/2011 - Dipodascus magnusii: A model for the study of autophagic processes (MJ)

  2. •UK/81/2011 - Functional analysis of the mitochondrial HMG-box containing protein from the yeast Yarrowia lipolytica (JP)

  3. •UK/162/2011 Relationship between DNA repair mechanisms and chromosome end stability in the yeast Saccharomyces cerevisiae (LS)

  4. •UK/361/2011 - Molecular principles of the control of metabolism of hydroxyaromatic compounds in yeasts (GG)

2010

  1. •UK/130/2010 - Functional analysis of genes involved in repair and recombination of the mitochondrial genome of the yeast Candida parapsilosis (EH)

2009

  1. •UK/218/09 - Characterization of the molecular architecture of mitochondrial genomes in yeasts from the genus Candida (MV)

  2. •UK/276/09 – Potential role of the MNX1 gene in the catabolism of benzene compounds in the pathogenic yeast C. parapsilosis (ZH)

  3. •UK/291/09 - Analysis of the structure and dynamics of mitochondrial nucleoids from in Candida parapsilosis (DF)

  4. •UK/309/2009 Study of biochemical and molecular-biology properties of mitochondrial HMG1 protein of the yeast Candida albicans (KV)

2008

  1. •UK/197/08 – Characterization of telomeres and telomere-binding proteins of the yeast Yarrowia lipolytica (SK)

  2. •UK/247/2008 Study of biochemical and molecular-biology properties of mitochondrial HMG1 protein of the yeast Candida albicans (KV)

  3. •UK/312/08 – Analysis of genes controlling the stability of the linear mitochondrial genome of the yeast Candida parapsilosis (DF)

  4. •UK/320/08 – Functional analysis of cell surface proteins CpWhp1p and CpWhp2p involved in the morphogenesis of the pathogenic yeast Candida parapsilosis (ZH)

  5. •UK/331/08 – Biochemical and genetical analysis of valinomycin effects on Saccharomyces cerevisiae cells (LA)

2007

  1. •UK/174/07 - The role of proteasome in yeast filamentous growth (ZH)

  2. •UK/190/07 - The role of YOL138c gene in ion homeostasis and telomere length maintenance (LA)

  3. •UK/191/07 - The role of CpMgm101 in linear mitochondrial genome replication (DF)

  4. •UK/200/07 - Identification and characterization of genes coding for telomerase RNA subunits in yeasts with long telomeric repeats (SG)

  5. •UK/250/07 - Characterization of telomeres and telomere-binding proteins in yeast Yarrowia lipolytica (SK)

2006

  1. •UK/149/06 - Analysis of the complete mitochondrial genome sequence of the non-conventional yeast Dipodascus magnusii (PK)

  2. •UK/234/06 - The study of telomeres nucleoprotein structure in the yeast Yarrowia lipolytica (SK)

  3. •UK/236/06 - The study of telomeres length and stability regulation in model organism - yeast Saccharomyces paradoxus (SG)

  4. •UK/237/06 - Mdm31p and Mdm32p - a connection between mitochondria volume control and mitochondrial ion homeostasis in yeasts (SP)

2005

  1. •UK/160/05 - The study of regulation of Taz1 gene expression and the characterization of interactions of telomeric proteins Taz1 and SpPot1 of the yeast Schizosaccharomyces pombe (SG)

  2. •UK/161/05 - Analysis of yeast genes potentially involved in regulation of homeostasis of mitochondrial ions (SP)

  3. •UK/181/05 - Determination of the complete mitochondrial genome sequences of the pathogenic yeasts Candida orthopsilosis and Candida metapsilosis (PK)

  4. •UK/210/05 - The role of yeast SSB proteins mtTBP and Rim1p in the replication of mitochondrial genomes (JZ)

2004

  1. •UK/195/04 - Design of an expression-purification system for mitochondrial SSB proteins and study of their properties in vitro (LL)

  2. •UK/204/04 - Genetic analysis of a preferential action of valinomycin and nigericin on yeast mitochondria (SP)

  3. •UK/230/04 - Biological role of adhesins in the yeast morphogenesis (PK)

2003

  1. •UK/53/03 - The role of Ras2 GTPase in iron metabolism of the yeast Saccharomyces cerevisiae (MK)

  2. •UK/135/03 - Identification and characterization of mitochondrial telomeres of the yeast Candida vartiovaare (JZ)

2002

  1. •UK/53/02 - Isolation and characterization of PIF1 gene in Candida parapsilosis (BK)

  2. •UK/54/02 - Screening of genes involved in iron homeostasis in Saccharomyces cerevisiae (MK)

  3. •UK/131/02 - Studies of Taz1p-telomere interaction in Schizosaccharomyces pombe (JS)

2000

  1. •UK/59/00 - Study of proteins Pif1p, Hmi2p and Rim1p involved in a replication of mitochondrial DNA of the yeast Saccharomyces cerevisiae (BK)

1999

  1. •UK/3690/99 - Study of protein-protein interactions of mitochondrial proteins Abf2p and Rim1p of the yeast Saccharomyces cerevisiae using a two-hybrid system (BK)

  2. •UK/3691/99 - Isolation and characterization of genes involved in morphogenesis of the yeast Dipodascus magnusii (MK)

1998

  1. •UK/3856/98 - Study of the regulation of mitochondrial telomere-binding protein of the yeast Candida parapsilosis on post-transcriptional and posttranslational levels (LT)

  2. •UK/3877/98 - Genetic transformation of yeast possessing linear mitochondrial genome: An application of the transformation system in the study of mitochondrial telomeres in vivo (JN)

1997

  1. •UK/1511/97 - Transformation systems for nonconventional yeasts as a tool toward the study of new biological phenomena (JN)

  2. •UK/1512/97 - Effect of the cAMP-dependent phosphorylation on the activity of mitochondrial DNA-binding proteins (LT)


Grants of Faculty of Natural Sciences (Comenius University) for PhD students:

2000

  1. •16/2000 - Study of regulation of cellular dimorphism in the yeast Yarrowia lipolytica (RS)